The history of stem cell studies dates back to the beginning of the 20-th century.
It was a Russian histologist named Alexander Maksimov who, in 1908, first put forward the existence of the stem cell (and coming up with the term himself) as part of his theory of hematopoietic. According to Maksimov’s hypothesis, all cellular blood components were derived from hematopoietic stem cells. Later A. Maksimov identified a singular type of precursor cell within mesenchyme that develops into different types of blood cells.
But it was only in the 1960s that the evidence of the existence of stem cells appeared. Russian scientist A. Friedenstein together with I. Chertkov were first to describe and prove experimentally the existence of multipotent mesenchymal stromal cells, referred to as colony-forming unit-fibroblasts. Almost at the same time, two scientists from Canada, James E. Till and Ernest A. McCulloch, demonstrated the existence of self-renewing cells found in the bone marrow of mice.
In 1968, a successful bone marrow transplant is conducted.
In 1978, the presence of haematopoietic SC is discovered in human cord blood cells.
In 1981 scientists Martin Evans, Matthew Kaufman and Gail R. Martin were able to derive embryonic stem cells out of the inner cell mass of a mouse’s blastocyst.
A link between Leukaemia and hematopoietic stem cells (from where the illness appears to originate) is established in 1997.
In 1998, scientists at the University of Wisconsin-Madison, led by James Thomson, were the first to derive human embryonic stem cells.
More discoveries have been made and are being made since: discovering of new sources of stem cells in children's primary teeth, human hair, umbilical cord blood, amniotic fluid; discovering of the Induced pluripotent stem cells (iPSs), successful cartilage regeneration in the human knee using autologous adult mesenchymal stem cells, and even producing stem cells from endangered species, that can save animals in danger of extinction.
The scientific researches in the field of stem cells technologies and their practical application are being carried on in different countries: the USA, Great Britain, Germany, Israel, Japan, Canada, Russia, etc.
Throughout the world research in stem cells is thriving. It is considered one of the most prospective fields of contemporary science, as the findings may possible bring cure to incurable diseases, higher quality of life to people, and longer life.
Our main partner in R&D is Medical Radiological Research Center in Russia, located in Obninsk, 100 km from Moscow. It has been at the origins of stem cell research and is now a stronghold of science and cutting-edge biotechnologies.
Following the creation of the world’s first nuclear power plant in Obninsk in 1954, the MRRC was set up to research new diagnostic, therapeutic and research techniques in medicine and biology through the use of radiation.
Doctor Anatoly Konoplyannikov is the head of this Center. He was one of the first who in 2003 successfully used mesenchymal stem cells in the operation on coronary artery bypass grafting, performed by a prominent Russian surgeon R. Akchurin. He uses stem cells technologies for treating patients with brain injury, disseminated sclerosis, apoplexy, diabetes, Crohn’s disease, kidney and liver diseases, tuberculosis, skin damages, allergies, eye diseases, etc.
We rely on this fundamental institution for our first-rate technologies and guarantee of the highest quality of stem cell therapy.
Located 100 km from Moscow, Obninsk is a science city and a hub of cutting-edge science and research.