Treatment of cirrhosis and other liver diseases

Ancient healers called the liver "the source of vital activity," The reason is clear. - It is this organ has a huge role in maintaining metabolism. What our body gets from there? Liver is: a sourse of amino acids, and fat metabolism also takes place in there. In addition, it neutralizes toxins, synthesis of bile which participates in the process of digestion, assimilation of vitamins, stimulates intestinal peristalsis.

Thus, normal metabolism in the body is impossible without proper liver function. That is why the most dangerous disease of the liver is cirrhosis. In this chronic disease, hepatocytes (liver parenchyma cells) lose their functionality and replaced by a scar (connective tissue). The most common causes of cirrhosis are alcohol, viral hepatitis (B, C, D), hereditary diseases, the effect of certain toxins and drugs, bile duct disease, parasitic infestation.

Viral and alcoholic cirrhosis are considered the most dangerous in adults. These types of cirrhosis most often turn into liver cancer and occur particularly hard. Epidemiological evidence suggests that cirrhosis affects hundreds of millions of people around the world and is particularly prevalent in the Asian region. Unfortunately, it is one of the most common causes of death in adults.

Treatment of cirrhosis is a major problem in modern hepatology. Not so long ago, this diagnosis was seen as a verdict, because the life of the patient after the appearance of the first clinical symptoms was usually only a few years. Traditionally, the treatment of cirrhosis consists of hepatoprotectors - drugs that protect liver cells from damage. An important role in the treatment of liver cirrhosis is also the correction of the patient's lifestyle and diet, the elimination of alcohol and other bad habits. Unfortunately, all these procedures only slightly improve the patient's condition, but don’t stop the progression of the disease. In especially severe cases, patients with cirrhosis get liver transplantation. Today it is a quite a effective method for treating acute hepatic failure and rapidly progressive cirrhosis. However, this kind of treatment is extremely limited due to the lack of donors, financial constraints and the risk of rejection after transplantation. In addition, the fibrosis again often develops in the transplanted liver in a year after transplantation.

An alternative cure, such as intravenous injection of stem cells, has been proposed more recently and became the most promising therapy for liver disease for nowadays. Numerous studies have demonstrated that mesenchymal stem cells (MSCs), the gold standard of which are Kintaro Cells, are capable of differentiating into functional liver cells-hepatocytes. After that, the affected liver regenerates by replacing the diseased cells with healthy ones. Therefore, in the last decade, patients with chronic degenerative diseases of the liver, primarily cirrhosis, get cellular therapy.

In addition, after injection, Kintaro Cells donor stem cells not only repair damaged tissues, but also produce biologically active substances that stimulate their own stem cells and, thereby, renew the cellular composition of the diseased organ. As a result, there is a rapid metabolism of hepatic toxins and stabilization of hemodynamic parameters, which is marked by a significant improvement in the biochemical parameters of the blood (albumin, bilirubin, ALT, AST). Mesenchymal stem cells have a feature - after the injection they independently migrate to the affected areas in the body. This is due to they have special chemoreceptors, such as those that are known in leukocytes. Thus, Kintaro Cells themselves find places that require treatment.

Also, the property of mesenchymal stem cells has been proven to inhibit the proliferation of hepatic stellate cells, called “Ito cells”. This discovery is successfully used in the cell therapy of liver fibrosis, since Ito cells are known to activated in the early stages of fibrogenesis.

Why are mesenchymal stem cells, in particular Kintaro Cells, ideal for cell therapy of liver disease?

• Kintaro Cells can be cultured from a small portion of the bone marrow cells of the donor;

• Kintaro Cells are able to selectively penetrate into damaged areas of organs and tissues, where they have angiogenic, antiapoptotic, antioxidant, antifibrotic, immunomodulating and mitogenic effects;

• Kintaro Cells trigger regeneration processes in other vital organs, such as the heart, brain, lungs, etc .;

• Kintaro Cells significantly improve the survival of transplanted liver;

• When using Kintaro Cells, there are no cancer risks specific to embryonic stem cells;

• there is the possibility of repeated injections, fixing a positive result;

• Kintaro Cells therapy is effective at all stages of liver disease treatment.


Patient from Russia, 42 years old, cirrhosis

After the hepatitis B, the patient was diagnosed with liver cirrhosis. Within 5 years, every 6 months, the patient must undergo treatment at the hospital. Before the treatment with stem cells, the patient had frequent nausea, weight loss, intermittent jaundice, a special diet, daily medications, as well as poor performance, and as a result, loss of work, problems in the family. The blood - a high level of bilirubin (up to 40), AST, ALT.

After receiving the full course of treatment with Kintaro Cells, all liver functions, ultrasound and blood samples were normalized (in which, 2 weeks after the first infusion, ALT level normalized, bilirubin level decreased, the patient felt more cheerful).




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